10.6084/m9.figshare.3555519.v1 Kalogirou C. Kalogirou C. Fender H. Fender H. Muck P Muck P Hey V. Hey V. Krebs M. Krebs M. Riedmiller H. Riedmiller H. Vergho D. Vergho D. Supplementary Material for: Long-Term Outcome of Nephron-Sparing Surgery Compared to Radical Nephrectomy for Renal Cell Carcinoma ≥4 cm - A Matched-Pair Single Institution Analysis Karger Publishers 2016 •Nephron-sparing surgery •Nephrectomy •Matched-pair •Large renal mass •Large renal tumour •Renal cell carcinoma 2016-08-09 14:37:53 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Long-Term_Outcome_of_Nephron-Sparing_Surgery_Compared_to_Radical_Nephrectomy_for_Renal_Cell_Carcinoma_4_cm_-_A_Matched-Pair_Single_Institution_Analysis/3555519 <p><b><i>Purpose:</i></b> We investigated the long-term oncological and functional outcome of nephron-sparing surgery/partial nephrectomy (PN) versus radical nephrectomy (RN) for any renal cell carcinoma (RCC) ≥4 cm. <b><i>Patients and Methods:</i></b> Between 1997 and 2013, we identified 128 patients undergoing PN for RCC ≥4 cm and matched this collective to 128 patients undergoing RN. We then compared overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS) and functional parameters in both groups. The median follow-up time was 58 months (3-210 months). <b><i>Results:</i></b> Compared to RN, patients with a PN showed a significantly higher 10-year OS (77.0 vs. 63.0%, p = 0.04), CSS (90.6 vs. 71.7%, p = 0.002) and PFS (82.9 vs. 57.4%, p ≤ 0.001). Renal function preservation was better in the PN group (24 months estimated glomerular filtration rate: 68.2 ml/min for PN vs. 40.6 ml/min for RN, p ≤ 0.01) with significantly less new onset chronic kidney diseases. Total complication rate was comparable, whereas PN procedures showed more Clavien-Dindo grade I + II complications, portraying the technical challenge of PN in larger RCCs. <b><i>Conclusions:</i></b> Whenever feasible, PN should be considered for renal masses ≥4 cm, as this technique shows better long-term results regarding disease-specific survival and renal function preservation in our study group.</p>