%0 Generic %A H., Xiong %A J., Huang %A X., Rong %A M., Zhang %A K., Huang %A R., Xu %A M., Wang %A C., Li %A Q., Liao %A W., Xia %A G., Luo %A X., Ye %A L., Lu %A Y., Fu %A T., Guo %A K., Nelson %D 2017 %T Supplementary Material for: HLA-B Alleles B*15:01 and B*15:02: Opposite Association with Hepatitis C Virus Infection in Chinese Voluntary Blood Donors %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_HLA-B_Alleles_B_15_01_and_B_15_02_Opposite_Association_with_Hepatitis_C_Virus_Infection_in_Chinese_Voluntary_Blood_Donors/4543093 %R 10.6084/m9.figshare.4543093.v1 %2 https://karger.figshare.com/ndownloader/files/7356568 %2 https://karger.figshare.com/ndownloader/files/7356571 %2 https://karger.figshare.com/ndownloader/files/7356574 %K Hepatitis C virus %K Chronic infection %K Human leukocyte antigens %K Alleles %K Chinese population %K Blood donor %X

Background: Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent in China, where the HCV prevalence is higher than the global average. Methods: In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, among whom the HLA alleles were sequenced using a high-resolution genotyping method. Results: At the 2-digit level, none of the alleles showed a statistical difference between the HCV-infected and uninfected groups. However, at the 4-digit level, the HLA-B alleles B*15:01 and B*15:02 showed an opposite association with HCV infection, i.e. B*15:01 was significantly higher in the HCV-infected group (odds ratio, OR = 1.561, p = 0.010), while B*15:02 was significantly higher in the uninfected group (OR = 0.778, p = 0.016). We also identified a higher frequency of B*13:02 in the HCV-infected group (OR = 1.515, p = 0.009) and a higher frequency of B*07:05 in the uninfected group (OR = 0.299, p = 0.001). Conclusions: The frequencies of four HLA alleles, B*07:05, B*13:02, B*15:01, and B*15:02, were found to be significantly different between the HCV-infected and uninfected blood donors in China, revealing an inverse relation of B*15:01 and B*15:02 with HCV infection. This finding suggests that the ethnic genetic variations of HLA may greatly affect the host immune responses against HCV.

%I Karger Publishers