10.6084/m9.figshare.4560703.v1
Errichetti E.
Errichetti
E.
Lallas A.
Lallas
A.
Apalla Z.
Apalla
Z.
Di Stefani A.
Di Stefani A.
Stinco G.
Stinco
G.
Supplementary Material for: Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study
Karger Publishers
2017
Dermoscopy
Granuloma annulare
Granulomatous skin diseases
Histology
Inflammoscopy
2017-01-18 14:23:24
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Dermoscopy_of_Granuloma_Annulare_A_Clinical_and_Histological_Correlation_Study/4560703
<p><b><i>Background:</i></b> Dermoscopy of granuloma annulare has been
investigated by several studies, but none of them took into account the
variability of dermoscopic findings according to clinical
characteristics and/or histological subtype. <b><i>Objective:</i></b> To
describe the dermoscopic features of classic granuloma annulare and
seek possible dermoscopic clues related to specific clinical
findings/histological subpatterns. <b><i>Methods:</i></b> A
representative dermoscopic image of a target lesion (the most active
lesion underwent histological examination) was retrospectively assessed
for the presence of specific morphological findings, correlating them
with clinical variables, i.e. disease duration and extension (localized
or generalized) and clinical aspect (annular or non-annular) and
localization (trunk or extremities) of the biopsied lesion, and with
histological subtype. <b><i>Results:</i></b> A total of 25 lesions from
25 subjects were analysed; an “interstitial” histological variant was
detected in 11 cases, while a “palisading granuloma” histological
pattern was found in 14 instances. The most common dermoscopic findings
included blurry vessels having variable appearance (dotted,
linear-irregular, and branching) over a more or less evident
pinkish-reddish background, followed by whitish and/or yellowish-orange
areas. Additional findings were rosettes, crystalline structures, and
whitish scaling. No difference (<i>p</i> > 0.05) in the frequency of
dermoscopic features according to clinical findings was found, while we
observed a strict association (<i>p</i> < 0.001) between the presence of yellowish-orange structureless areas on dermoscopy and “palisading granuloma” histology. <b><i>Conclusion:</i></b>
The dermoscopic aspect of granuloma annulare is independent from
clinical features but varies according to histological subtype, with the
detection of yellowish-orange colour being indicative of the
“palisading granuloma” variant.</p>