10.6084/m9.figshare.4580890.v1
Wolfgram D.F.
Wolfgram
D.F.
Garcia K.
Garcia
K.
Evans G.
Evans
G.
Zamanian S.
Zamanian
S.
Tang R.
Tang
R.
Wiegmann T.
Wiegmann
T.
Sharma R.
Sharma
R.
Campbell R.
Campbell
R.
Whittle J.
Whittle
J.
for the SPRINT Study Research Group
for the SPRINT Study Research
Group
Supplementary Material for: Association of Albuminuria and Estimated Glomerular Filtration Rate with Functional Performance Measures in Older Adults with Chronic Kidney Disease
Karger Publishers
2017
Functional impairment
Albuminuria
Chronic kidney disease
2017-01-24 15:09:34
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_of_Albuminuria_and_Estimated_Glomerular_Filtration_Rate_with_Functional_Performance_Measures_in_Older_Adults_with_Chronic_Kidney_Disease/4580890
<p><b><i>Background:</i></b> Chronic kidney disease (CKD) is
increasingly common and disproportionately affects older adults. The
contribution of kidney disease to the functional impairment noted in the
elderly CKD population is unclear. <b><i>Methods:</i></b> This is a
cross-sectional analysis of a hypertensive cohort of people aged ≥75
years from the Systolic Blood Pressure Intervention Trial. We evaluated
estimated glomerular filtration rate (eGFR) and urine
albumin-to-creatinine ratio (UACR) as predictors of 3 measures of
functional status: EuroQol-5 Dimensional (EQ-5D) score, Falls Efficacy
Scale (FES) score, and gait speed. Linear regression models were used to
evaluate the associations between our independent variables and outcome
measures. <b><i>Results:</i></b> Our analysis included 2,620
participants, mean age of 79.9 (4.0) years. Unadjusted models showed
that lower eGFR level and higher UACR level were associated with lower
EQ-5D (<i>p</i> < 0.001 for both) and slower gait speed (<i>p</i> < 0.001 for both) and worse scores on FES (<i>p</i> = 0.032 and <i>p</i>
= 0.039). In the fully adjusted models, higher levels of UACR remained
significantly associated with lower EQ-5D scores and slower gait speed (<i>p</i> = 0.011 and <i>p</i>
= 0.002, respectively). In contrast, level of eGFR was not associated
with any functional outcome measures when accounting for covariates. <b><i>Conclusions:</i></b>
In individuals aged ≥75 years, albuminuria and eGFR were associated
with impairments in physical performance and self-reported functional
status; however, only the association with albuminuria remained after
adjusting for relevant demographics and comorbidities. Evaluation of
albuminuria may provide an additional tool for identifying older
individuals at risk for functional impairment.</p>