Supplementary Material for: Comprehensive, Individualized, Person-Centered Management of Community-Residing Persons with Moderate-to-Severe Alzheimer Disease: A Randomized Controlled Trial
Reisberg B.
Shao Y.
Golomb J.
Monteiro I.
Torossian C.
Boksay I.
Shulman M.
Heller S.
Zhu Z.
Atif A.
Sidhu J.
Vedvyas A.
Kenowsky S.
10.6084/m9.figshare.4585201.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Comprehensive_Individualized_Person-Centered_Management_of_Community-Residing_Persons_with_Moderate-to-Severe_Alzheimer_Disease_A_Randomized_Controlled_Trial/4585201
<p><b><i>Background/Aims: </i></b>The aim was to examine added benefits
of a Comprehensive, Individualized, Person-Centered Management (CI-PCM)
program to memantine treatment. <b><i>Methods: </i></b>This was a
28-week, clinician-blinded, randomized, controlled, parallel-group
study, with a similar study population, similar eligibility criteria,
and a similar design to the memantine pivotal trial of Reisberg et al.
[N Engl J Med 2003;348:1333-1341]. Twenty eligible community-residing
Alzheimer disease (AD) subject-caregiver dyads were randomized to the
CI-PCM program (n = 10) or to usual community care (n = 10). Primary
outcomes were the New York University Clinician's Interview-Based
Impression of Change Plus Caregiver Input (NYU-CIBIC-Plus), assessed by
one clinician set, and an activities of daily living inventory, assessed
by a separate clinician set at baseline and at weeks 4, 12, and 28. <b><i>Results: </i></b>Primary
outcomes showed significant benefits of the CI-PCM program at all
post-baseline evaluations. Improvement on the NYU-CIBIC-Plus in the
management group at 28 weeks was 2.9 points over the comparator group.
The memantine 2003 trial showed an improvement of 0.3 points on this
global measure in memantine-treated versus placebo-randomized subjects
at 28 weeks. Hence, globally, the management program intervention
benefits were 967% greater than memantine treatment alone. <b><i>Conclusion: </i></b>These
results are approximately 10 times those usually observed with both
nonpharmacological and pharmacological treatments and indicate
substantial benefits with the management program for advanced AD
persons.</p>
2017-01-25 14:32:47
Dementia
Activities of daily living
Behavioral symptoms
Comprehensive health care
Caregivers
Community health care
Patient-centered care
Person-centered therapy
Delivery of health care
Community health education