10.6084/m9.figshare.4602112.v1 Shen W. Shen W. Aguilar R. Aguilar R. Montero A.R. Montero A.R. Fernandez S.J. Fernandez S.J. Taylor A.J. Taylor A.J. Wilcox C.S. Wilcox C.S. Lipkowitz M.S. Lipkowitz M.S. Umans J.G. Umans J.G. PowerPoint Slides for: Acute Kidney Injury and In-Hospital Mortality after Coronary Artery Bypass Graft versus Percutaneous Coronary Intervention: A Nationwide Study Karger Publishers 2017 Acute kidney injury Renal replacement therapy In-hospital mortality Coronary artery bypass graft Percutaneous coronary intervention 2017-02-01 12:34:22 Presentation https://karger.figshare.com/articles/presentation/PowerPoint_Slides_for_Acute_Kidney_Injury_and_In-Hospital_Mortality_after_Coronary_Artery_Bypass_Graft_versus_Percutaneous_Coronary_Intervention_A_Nationwide_Study/4602112 <p><b><i>Background:</i></b> Post-procedural acute kidney injury (AKI) is associated with significantly increased short- and long-term mortalities, and renal loss. Few studies have compared the incidence of post-procedural AKI and in-hospital mortality between 2 major modalities of revascularization - coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) - and results have been inconsistent. <b><i>Methods:</i></b> We generated a propensity score-matched cohort that includes a total of 286,670 hospitalizations with multi-vessel coronary disease undergoing CABG or PCI (2004-2012) from the National Inpatient Sample database. We compared incidence of AKI, AKI requiring renal replacement therapy (RRT), in-hospital mortality, hospital stay, and charges between CABG and PCI groups. <b><i>Results:</i></b> The incidence of AKI after CABG was higher than PCI (8.9 vs. 4.5%, OR 2.05, 95% CI 1.99-2.12, <i>p</i> < 0.001). The incidence of AKI requiring RRT was also higher after CABG (1.1 vs. 0.5%, OR 2.14, 95% CI 1.96-2.34, <i>p</i> < 0.001). Likewise, in-hospital mortality was higher after CABG than PCI (2.0 vs. 1.4%, OR 1.44, 95% CI 1.35-1.52, <i>p</i> < 0.001). Among patients with pre-existing chronic kidney disease (stages I-IV), those undergoing CABG was associated with 2.0-2.3-fold higher odds of developing AKI than those undergoing PCI. The patients treated with CABG had a significantly longer hospital stay and higher hospital charges. <b><i>Conclusions:</i></b> Patients undergoing CABG are associated with (1) increased risk of developing post-procedural AKI, (2) higher likelihood of receiving RRT, and (3) worse short-term survival. Long-term renal outcome remains to be studied.</p>