10.6084/m9.figshare.4609396.v1
Eliassen C.F.
Eliassen
C.F.
Reinvang I.
Reinvang
I.
Selnes P.
Selnes
P.
Fladby T.
Fladby
T.
Hessen E.
Hessen
E.
Supplementary Material for: Convergent Results from Neuropsychology and from Neuroimaging in Patients with Mild Cognitive Impairment
Karger Publishers
2017
Mild cognitive impairment
Neuropsychology
Cognition
Memory
Executive function
Magnetic resonance imaging
Atrophy
Positron emission tomography
Metabolism
2017-02-02 13:25:07
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Convergent_Results_from_Neuropsychology_and_from_Neuroimaging_in_Patients_with_Mild_Cognitive_Impairment/4609396
<p><b><i>Background/Aims:</i></b> To investigate the correspondence
between neuropsychological single measures and variation in
fludeoxyglucose positron emission tomography (FDG PET) glucose
metabolism and magnetic resonance imaging (MRI) cortical thickness in
mild cognitive impairment (MCI) patients. <b><i>Methods:</i></b>
Forty-two elderly controls and 73 MCI subjects underwent FDG PET and MRI
scanning. Backward regression analyses with PET and MRI regions were
used as dependent variables, while Rey Auditory Verbal Memory Test
(RAVLT) recall, Trail Making Test B (TMT B), and a composite test score
(RAVLT learning and immediate recall, TMT A, COWAT, and letter-number
sequencing) were used as predictor variables. <b><i>Results:</i></b> The
composite score predicted variation in cortical metabolism;
supplementary analyses showed that TMT B was significantly correlated
with PET metabolism as well. RAVLT and TMT B were significant predictors
of variation in MRI cortical thickness. <b><i>Conclusion:</i></b> Our results indicate that RAVLT and TMT B are sensitive to variation in Alzheimer disease neuroimaging markers.</p>