%0 Generic %A Q., Fan %A Y., Yan %A L., Gu %A L., He %A N., Chen %A G., Jiang %A L., Yuan %A J., Xue %A Y., Zhang %A J., Ma %A H., Jin %A W., Yuan %A Z., Guo %A L., Guo %A N., Wang %A W., Zhang %A Z., Ye %A P., Mao %A X., Pi %A R., Lu %A M., Zhu %A Weiming, Zhang %A Z., Ni %A J., Qian %A H., Pang %D 2017 %T Supplementary Material for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Prognostic_Value_of_the_Delivery_Dialysis_Dose_on_Twice-Weekly_Hemodialysis_Patients/4626163 %R 10.6084/m9.figshare.4626163.v1 %2 https://karger.figshare.com/ndownloader/files/7526479 %K Cardiovascular disease %K Dialysis adequacy %K Dialysis dose %K Hemodialysis %K Residual kidney function %K Health-related quality of life %X

Background: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD. Methods: This is a multicenter randomized controlled trial performed on 163 patients from 17 dialysis centers in Shanghai who were allocated to high- (n = 98) and standard-dose groups (n = 65) and followed through 96 weeks of study period. Therapeutic approaches were given to increase spKt/V to over 1.70 in the high-dose group. Data were collected every 12-24 weeks. The primary outcomes were all-cause mortality and major adverse cardio-cerebrovascular events (MACEs) occurrence, and secondary outcomes included residual kidney function (RKF) and health-related quality of life (HR-QOL). Results: The spKt/V in high-dose and standard-dose groups were 1.80 ± 0.23 and 1.55 ± 0.19, respectively, after an 8-week intervention (p < 0.001). At the end of the study, SF-36 physical function and total score in high-dose group were 82 (69-90) and 74 (47-84), respectively, both of which were higher than those in the standard-dose group. Decline in urine volume was observed in both groups with no significant difference (p = 0.431). No difference was found in overall survival between the 2 groups (p = 0.580). The 1-year MACE-free survival for high-dose group was 84.49%, better than 76.72% for standard-dose group (p = 0.029). Conclusions: Higher spKt/V is also associated with MACE-free survival and better HR-QOL, especially in physical function aspect for twice-weekly dialysis patients. Increasing spKt/V over 1.70 in twice-weekly HD population does not cause loss of RKF.

%I Karger Publishers