10.6084/m9.figshare.4793722.v1
Ferré N.
Ferré
N.
Rubio-Torrents C.
Rubio-Torrents
C.
Luque V.
Luque
V.
Closa-Monasterolo R.
Closa-Monasterolo
R.
Grote V.
Grote
V.
Koletzko B.
Koletzko
B.
Socha P.
Socha
P.
Gruszfeld D.
Gruszfeld
D.
Langhendries J.P.
Langhendries
J.P.
Sengier A.
Sengier
A.
Verduci E.
Verduci
E.
Escribano J.
Escribano
J.
for the European Childhood Obesity Project Group
for the European Childhood Obesity Project
Group
Supplementary Material for: Influence of Feeding Types during the First Months of Life on Calciuria Levels in Healthy Infants: A Secondary Analysis from a Randomized Clinical Trial
Karger Publishers
2017
Calciuria
Feeding type
Infants
Protein intake
2017-03-28 13:51:29
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Influence_of_Feeding_Types_during_the_First_Months_of_Life_on_Calciuria_Levels_in_Healthy_Infants_A_Secondary_Analysis_from_a_Randomized_Clinical_Trial/4793722
<p><b><i>Background/Aims:</i></b> Dietary factors can modify calciuria.
We aim to investigate urinary calcium excretion in healthy infants
according to their protein. <b><i>Methods:</i></b> Secondary data
analysis from a randomized clinical trial where healthy term infants
were randomized after birth to a higher (HP) or lower (LP) protein
content formula that was consumed until age 1 year. A non-randomized
group of breastfed (BF) infants was used for reference. Anthropometry,
dietary intakes and calciuria (calcium/creatinine ratios) from spot
urine samples were assessed at ages 3 and 6 months. At 6 months, the
kidney volumes were assessed using ultrasonography, and the serum urea
and creatinine levels were determined. <b><i>Results:</i></b> BF infants showed the highest calciuria levels, followed by the HP and the LP groups (<i>p</i>
< 0.001 for all comparisons). Either protein intakes or formula
types modulated the calciuria in linear regression models adjusted for
other influencing dietary factors. The usual cut-off values classified
37.8% (BF), 16.8% (HP) and 4.9% (LP) of the infants as hypercalciuric. <b><i>Conclusions:</i></b>
Feeding types during the first months of life affect calciuria, with BF
infants presenting the highest levels. We propose new cut-off values,
based on feeding types, to prevent the overestimation in hypercalciuria
diagnoses among BF infants.</p>