Supplementary Material for: Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis
Pinart M.
Keller T.
Reich A.
Fröhlich M.
Cabieses B.
Hohmann C.
Postma D.S.
Bousquet J.
Antó J.M.
Keil T.
10.6084/m9.figshare.4929773.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Sex-Related_Allergic_Rhinitis_Prevalence_Switch_from_Childhood_to_Adulthood_A_Systematic_Review_and_Meta-Analysis/4929773
<p><b><i>Background:</i></b> A sex-related switch in the prevalence of
asthma from childhood (male predominance) to adulthood (female
predominance) has been described, but for allergic rhinitis this remains
unclear. We aimed to examine sex- and age-group-specific differences in
allergic rhinitis prevalence by systematically evaluating studies from
across the globe. <b><i>Methods:</i></b> A systematic search of MEDLINE
and Embase for population-based cross-sectional studies was performed
regardless of the language of publication. The search was restricted to
the present millennium (2000 to June 2014). Study quality was defined by
the sampling method, response rate, sample size, and data collection
method. To assess sex differences in the prevalence of self- or
parent-reported symptoms of rhinitis, calculated pooled estimates of the
male-female ratio (MFR) were obtained using random-effects model
meta-analyses due to heterogeneity. A meta-regression analysis was also
performed. <b><i>Results:</i></b> Out of 6,539 publications identified,
67 cross-sectional population-based studies (291,726 males and 301,781
females) were included in our meta-analysis. In children (<11 years
of age) significantly more boys than girls had rhinitis symptoms (MFR
1.21, 95% CI 1.17-1.25), whereas in adolescents (11 to <18 years of
age) males were significantly less often affected than females (MFR
0.90, 95% CI 0.85-0.95). No sex-specific prevalence difference was
observed in adults (MFR 0.96, 95% CI 0.83-1.17). These findings were
consistent in all continents except in Asia, where the male predominance
remained beyond childhood. <b><i>Conclusions:</i></b> The male
predominance of rhinitis prevalence in childhood changed towards a
female predominance in adolescence across the globe, except in Asia.
Longitudinal studies are needed to confirm these cross-sectional data
and examine possible determinants and underlying mechanisms.</p>
2017-04-28 10:50:48
Allergic rhinitis
Meta-analysis
Prevalence
Sex differences
Systematic review