Supplementary Material for: Is Regular Screening for Intracranial Aneurysm Necessary in Patients with Autosomal Dominant Polycystic Kidney Disease? A Systematic Review and Meta-analysis
Zhou Z.
Xu Y.
Delcourt C.
Shan J.
Li Q.
Xu J.
Hackett M.L.
10.6084/m9.figshare.5001956.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Is_Regular_Screening_for_Intracranial_Aneurysm_Necessary_in_Patients_with_Autosomal_Dominant_Polycystic_Kidney_Disease_A_Systematic_Review_and_Meta-analysis/5001956
<p><b><i>Background:</i></b> The prevalence of intracranial aneurysm in
patients with autosomal dominant polycystic kidney disease (ADPKD) is
higher than that among the general population. We performed a systematic
review and meta-analysis on the prevalence and natural history of
intracranial aneurysm among patients with ADPKD. <b><i>Methods:</i></b>
Medline, Embase, Web of Science and Scopus, from inception to July 2016,
were searched for studies reporting the occurrence of intracranial
aneurysms among participants with ADPKD. Two authors independently
assessed the eligibility of all retrieved studies and extracted data.
Information on the prevalence of intracranial aneurysms and their
natural history in participants with ADPKD was collected from all
included studies. <b><i>Results:</i></b> Fifteen studies with 1,490
participants with ADPKD were pooled to study about the prevalence of
intracranial aneurysm in participants with ADPKD, and the prevalence
rate was found to be 10% (95% CI 7-13%). Studies from China, Japan and
Europe (Germany, Poland) reported a higher prevalence of intracranial
aneurysm. Having a family history of haemorrhagic stroke or intracranial
aneurysm was a risk factor for aneurysm occurrence. Twenty-three
percent (95% CI 15-31%) of the participants had multiple aneurysms. Most
of the aneurysms were small (<6 mm) and located in the anterior
circulation. Five studies with 171 participants (83 with 106 aneurysms
at baseline and 88 without) were analyzed to understand the natural
history of aneurysms, with an incidence of aneurysm growth, new aneurysm
and aneurysm rupture of 1.84% (followed up for 435 person-years), 0.57%
(1,227 person-years) and 0.13% (792 person-years) respectively. <b><i>Conclusions:</i></b>
Screening for intracranial aneurysm is recommended in patients with
ADPKD when there is a family history of haemorrhagic stroke or
intracranial aneurysm and when they are from China, Japan or Europe
(Germany, Poland). Based on existing data, regular imaging follow-up is
not supported. High-quality, prospective studies are needed in the
future.</p>
2017-05-12 09:27:12
Intracranial aneurysm
Autosomal dominant polycystic kidney disease
Follow-up study
Magnetic resonance angiography