Supplementary Material for: Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus
Ferreira A.
Felipe C.
Cristelli M.
Viana L.
Basso G.
Stopa S.
Mansur J.
Ivani M.
Bessa A.
Ruppel P.
Aguiar W.
Campos E.
Gerbase-DeLima M.
Proença H.
Tedesco-Silva H.
Medina-Pestana J.
10.6084/m9.figshare.5008799.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Donor-Specific_Anti-Human_Leukocyte_Antigens_Antibodies_Acute_Rejection_Renal_Function_and_Histology_in_Kidney_Transplant_Recipients_Receiving_Tacrolimus_and_Everolimus/5008799
<p><b><i>Background:</i></b> This analysis compared efficacy, renal
function, and histology in kidney transplant recipients receiving
tacrolimus (TAC) combined with everolimus (EVR) or mycophenolate (MPS). <b><i>Methods:</i></b>
This was a retrospective analysis from a randomized trial in kidney
transplant recipients who received a single 3 mg/kg dose of rabbit
antithymocyte globulin (r-ATG), TAC, EVR, and prednisone (PRED;
r-ATG/EVR, <i>n</i> = 85), basiliximab (BAS), TAC, EVR, and PRED (BAS/EVR, <i>n</i> = 102) or BAS, TAC, MPS, and PRED (BAS/MPS, <i>n</i>
= 101). We evaluated the incidence of de novo donor-specific anti-human
leukocyte antigens antibodies (DSA) and histology on protocol biopsies
at 12 months, and the incidence of acute rejection, estimated glomerular
filtration rate (eGFR) and proteinuria at 36 months. <b><i>Results:</i></b>
At 12 months, there were no differences in de novo DSA (6.4 vs. 3.4 vs.
5.5%) or in subclinical inflammation (2.0 vs. 4.8 vs. 10.2%),
interstitial fibrosis/tubular atrophy (57.1 vs. 58.5 vs. 53.8%) and C4d
deposition (2.0 vs. 7.3 vs. 2.6%). At 36 months, there were no
differences in the incidence of treatment failure (19.0 vs. 27.7 vs.
27.7%, <i>p</i> = 0.186), first biopsy-proven acute rejection (9.5 vs. 21.8 vs. 16.8%, <i>p</i>
= 0.073), and urine protein/creatinine ratios (0.53 ± 1.05 vs. 0.62 ±
0.75 vs. 0.71 ± 1.24). eGFR was lower in the BAS/EVR compared to that in
the BAS/MPS group (53.4 ± 20.9 vs. 50.8 ± 19.5 vs. 60.7 ± 21.2
mL/min/1.73 m<sup>2</sup>, <i>p</i> = 0.017) but comparable using a sensitive analysis (49.5 ± 23 vs. 47.5 ± 22.6 vs. 53.6 ± 27.8 mL/min/1.73 m<sup>2</sup>, <i>p</i> = 0.207). <b><i>Conclusion:</i></b>
In this cohort, the use of EVR and reduced TAC concentrations were
associated with comparable efficacy, renal function, and histological
parameters compared to the standard-of-care immunosuppressive regimen.</p>
2017-05-16 13:01:39
Renal function
Tacrolimus
Everolimus