10.6084/m9.figshare.5091967.v1
Ramirez-Gomez L.
Ramirez-Gomez
L.
Zheng L.
Zheng
L.
Reed B.
Reed
B.
Kramer J.
Kramer
J.
Mungas D.
Mungas
D.
Zarow C.
Zarow
C.
Vinters H.
Vinters
H.
Ringman J.M.
Ringman
J.M.
Chui H.
Chui
H.
Supplementary Material for: Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort
Karger Publishers
2017
Alzheimer disease
Subcortical ischemic vascular dementia
Neuropathology
Vascular cognitive impairment
Memory performance
2017-06-08 11:27:41
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Neuropsychological_Profiles_Differentiate_Alzheimer_Disease_from_Subcortical_Ischemic_Vascular_Dementia_in_an_Autopsy-Defined_Cohort/5091967
<p><b><i>Background/Aims:</i></b> The aim of this study was to assess
the ability of neuropsychological tests to differentiate autopsy-defined
Alzheimer disease (AD) from subcortical ischemic vascular dementia
(SIVD). <b><i>Methods:</i></b> From a sample of 175 cases followed
longitudinally that underwent autopsy, we selected 23 normal controls
(NC), 20 SIVD, 69 AD, and 10 mixed cases of dementia. Baseline
neuropsychological tests, including Memory Assessment Scale word list
learning test, control oral word association test, and animal fluency,
were compared between the three autopsy-defined groups. <b><i>Results:</i></b>
The NC, SIVD, and AD groups did not differ by age or education. The
SIVD and AD groups did not differ by the Global Clinical Dementia Rating
Scale. Subjects with AD performed worse on delayed recall (<i>p</i>
< 0.01). A receiver operating characteristics analysis comparing the
SIVD and AD groups including age, education, difference between
categorical (animals) versus phonemic fluency (letter F), and the first
recall from the word learning test distinguished the two groups with a
sensitivity of 85%, specificity of 67%, and positive likelihood ratio of
2.57 (AUC = 0.789, 95% CI 0.69-0.88, <i>p</i> < 0.0001). <b><i>Conclusion:</i></b>
In neuropathologically defined subgroups, neuropsychological profiles
have modest ability to distinguish patients with AD from those with
SIVD.</p>