A., Zimmermann P., Grigorescu-Sido C., AlKhzouz K., Patberg S., Bucerzan E., Schulze T., Zimmermann H., Rossmann H.-C., Geiss K.J., Lackner Supplementary Material for: Alterations in Lipid and Carbohydrate Metabolism in Patients with Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency <i>Background:</i> Classic 21-hydroxylase deficiency (21HD) presents some traits of the metabolic syndrome. <i>Aim:</i> To characterize discrete alterations of lipid and carbohydrate metabolism in children and young adults with classic 21HD, which could predict early atherogenesis. <i>Patients and Methods:</i> Twenty-seven Caucasian patients with classic 21HD (4–31 years); 27 sex-, age- and BMI-matched controls. Clinical parameters, hormonal status and genotype were assessed in all patients. Lipid parameters, including relative (%) and absolute (mg/dl) small-dense low-density lipoproteins subfractions (sd-LDL) were measured in patients and controls. Oral glucose tolerance tests were performed in both groups. <i>Results:</i> sd-LDL (%) was significantly higher in patients than controls (39.7 ± 5.9 vs. 35.5 ± 5.7%; p = 0.008). The same applies for absolute sd-LDL (mg/dl) (42.6 ± 11.9 vs. 36.4 ± 7.5; p = 0.029). HDL-cholesterol was lower in patients (p = 0.032). Fasting glucose and insulin were significantly higher in patients. Similar differences were noticed for HOMA-IR (p = 0.001), IRI (p = 0.001) and HOMA-B (p = 0.002). IRI correlated directly and significantly with the total hydrocortisone dose and the duration of treatment. Fasting glucose correlated with absolute sd-LDL. No obvious differences were seen between clinical forms or genotype groups. <i>Conclusions:</i> Substitution therapy should be adapted particularly at young ages to prevent early atherogenesis and cardiovascular risk in later life. 21-Hydroxylase;Small-dense low-density lipoproteins;Atherogenesis 2010-04-15
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Alterations_in_Lipid_and_Carbohydrate_Metabolism_in_Patients_with_Classic_Congenital_Adrenal_Hyperplasia_due_to_21-Hydroxylase_Deficiency/5121163
10.6084/m9.figshare.5121163.v1