%0 Generic
%A J., Li
%A X., Wu
%A X., Li
%A G., Feng
%A L., He
%A Y., Shi
%D 2010
%T Supplementary Material for: The Endothelial Nitric Oxide Synthase Gene Is Associated with Coronary Artery Disease: A Meta-Analysis
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Endothelial_Nitric_Oxide_Synthase_Gene_Is_Associated_with_Coronary_Artery_Disease_A_Meta-Analysis/5121232
%R 10.6084/m9.figshare.5121232.v1
%2 https://karger.figshare.com/ndownloader/files/8705686
%K Endothelial nitric oxide synthase gene
%K Coronary artery disease
%K Meta-analysis
%X Introduction: Previous case-control studies have suggested that the endothelial nitric oxide synthase (eNOS) gene polymorphisms (G894T, 4b/a, T-786C) are associated with coronary artery disease (CAD). However, other studies do not confirm these relationships. The objective was to assess these relationships using meta-analysis. Methods: Databases, including Pubmed and Embase, were searched to access the relevant genetic association studies up to July 2009. Results: The meta-analysis included 56 studies, consisting of 23 studies for G894T, 19 for 4b/a and 14 for T-786C. For the allelic analysis of the G894T variant, all studies showed a positively significant association (OR = 0.83, p = 0.004). For the genotypic analysis, the combined studies of the T allele showed significance (OR = 1.57, p = 0.003). For the allelic analysis of the T-786C variant, all studies showed an obviously significant association (OR = 0.79, p = 0.0007), reflected in both non-Asian and Asian studies. For the genotype analysis, combined studies of the C allele showed significance (OR = 0.72, p = 0.0001). Moreover, non-Asian studies showed significant results. For the analysis of the 4b/a variant, none of the studies showed significant results. No publication bias was found in the meta-analysis. Conclusion: The synthesis of available evidence supports the fact that eNOS G894T andT-786C are associated with CAD.
%I Karger Publishers