Supplementary Material for: Association of Genetic Polymorphisms in <i>STAT1</i> Gene with Increased Risk of Hepatocellular Carcinoma
Zhu Z.-Z.
Di J.-Z.
Gu W.-Y.
Cong W.-M.
Gawron A.
Wang Y.
Zheng Q.
Wang A.-Z.
Zhu G.
Zhang P.
10.6084/m9.figshare.5121418.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_of_Genetic_Polymorphisms_in_i_STAT1_i_Gene_with_Increased_Risk_of_Hepatocellular_Carcinoma/5121418
<i>Objective:</i> Although signal transducer and activator of transcription 1 (STAT1), a transcription factor, plays a critical role in carcinogenesis and has been implicated as a tumor suppressor, few studies have investigated the associations between polymorphisms of this gene and the risk of cancer development. The aim of this study was to examine whether <i>STAT1</i> gene polymorphisms are associated with the risk of hepatocellular carcinoma (HCC). <i>Methods:</i> Ten single nucleotide polymorphisms in the <i>STAT1</i> gene were genotyped by TaqMan assays in 469 HCC cases and 558 age-, sex- and HBsAg-matched controls in a Chinese population. <i>Results:</i> Minor allele homozygous genotypes at rs867637 (9,046 bp 3′ of STP A>G), rs3771300 (IVS24–153T>G), and rs2280235 (IVS20–103G>A), compared with their homozygote genotypes of common alleles, were associated with 1.6- (95% CI 1.1–2.3), 1.6- (95% CI 1.1–2.4), and 1.4-fold (95% CI 0.95–1.9) increased risk of HCC, respectively. The GGA haplotype, comprised of risk alleles at rs867637, rs3771300 and rs2280235, conferred a 1.2-fold (95% CI 1.0–1.5) increased risk of HCC, as compared to the most common haplotype of ATG. Diplotype GGA/GGA conferred a 1.6-fold (95% CI 1.0–2.5) increased risk of HCC compared with diplotype ATG/ATG. <i>Conclusion:</i> Our results demonstrate for the first time that polymorphisms in the <i>STAT1</i> gene are associated with HCC susceptibility.
2010-08-27 00:00:00
Hepatocellular carcinoma
Polymorphisms
STAT1