Supplementary Material for: Bilateral Internuclear Ophthalmoplegia in a Patient with Devic’s Neuromyelitis Optica Garcia-Martin E. Pinilla I. Pueyo V. Gil L. Martinez-Morales J. Fernandez J. 10.6084/m9.figshare.5121565.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Bilateral_Internuclear_Ophthalmoplegia_in_a_Patient_with_Devic_s_Neuromyelitis_Optica/5121565 An unusual presentation of Devic’s neuromyelitis optica (NMO) disease associated with bilateral internuclear ophthalmoplegia (INO) is described. A 32-year-old pregnant patient was diagnosed with NMO. First symptoms were headache and sudden visual loss in her right eye (RE). Eighteen months ago, she reported other neurologic symptoms such as paresthesia. Based on her visual field, fundoscopy and Ishihara test, she was diagnosed with retrobulbar neuritis of the RE. After delivery, new neurologic symptoms resembling transverse myelitis appeared. She was treated with methylprednisolone and plasmapheresis, which improved her visual acuity; however, a sudden bilateral INO appeared, with adduction defect and nystagmus with abduction in both eyes. No improvement was obtained after treatment with azathioprine and rituximab. Paresis of the legs and the right arm persisted, but double vision and OIN gradually disappeared. At the end, the patient had a residual exophoria in the RE and nystagmus with abduction in the left eye. Prevalence of NMO is lower than one case per one million inhabitants, and it is not likely to affect the encephalic trunk; furthermore, bilateral INO in NMO is rare. Two major criteria and at least two of the three minor ones are required to confirm a NMO diagnosis, and our patient fulfilled these diagnosis criteria. 2010-11-12 00:00:00 Visual loss Retrobulbar neuritis Nystagmus Devic’s neuromyelitis optica Bilateral internuclear ophthalmoplegia