10.6084/m9.figshare.5121700.v1 Cheng D. Cheng D. Noble J. Noble J. Tang M.X. Tang M.X. Schupf N. Schupf N. Mayeux R. Mayeux R. Luchsinger J.A. Luchsinger J.A. Supplementary Material for: Type 2 Diabetes and Late-Onset Alzheimer’s Disease Karger Publishers 2011 Type 2 diabetes Alzheimerߣs disease 2011-07-15 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Type_2_Diabetes_and_Late-Onset_Alzheimer_s_Disease/5121700 <i>Background/Aims:</i> To confirm in a cohort recruited in 1999–2001 our finding in a cohort recruited in 1992–1994 relating type 2 diabetes (T2D) to late-onset Alzheimer’s disease (LOAD). <i>Methods:</i> Participants were 1,488 persons aged 65 years and older without dementia at baseline from New York City. T2D was ascertained by self-report. Dementia and LOAD were ascertained by standard research procedures. Proportional hazard regression was used for analyses relating T2D and LOAD. <i>Results:</i> The prevalence of T2D was 17%. There were 161 cases of dementia and 149 cases of LOAD. T2D was related to dementia (hazard ratio = 1.7; 95% confidence interval = 1.4–2.9) and LOAD (1.6; 1.0–2.6) after adjustment for age, sex, education, ethnic group and apolipoprotein E Ε4. This association was weaker when only AD – excluding cases of mixed dementia – was considered (hazard ratio = 1.3; 95% confidence interval = 0.8–2.2). <i>Conclusion: </i>T2D is associated with LOAD. Cerebrovascular disease may be an important mediator.