Supplementary Material for: Standardized Renal Endpoints for Perioperative Clinical Trials: The Standardized Endpoints in Perioperative Medicine Initiative
McIlroy D.R.
Shaw A.D.
Myles P.S.
10.6084/m9.figshare.5122339.v1
https://karger.figshare.com/articles/figure/Supplementary_Material_for_Standardized_Renal_Endpoints_for_Perioperative_Clinical_Trials_The_Standardized_Endpoints_in_Perioperative_Medicine_Initiative/5122339
<p>Perioperative acute kidney injury is a common problem. While clinical
trials seek to evaluate the impact of interventions on a variety of
primary and secondary endpoints with the aim of implementing this
knowledge to improve perioperative outcomes, the use of valid and
relevant endpoints within clinical trials is of critical importance to
achieving this goal. Suitable endpoints must be validated for the study
population and in light of the clinical context under investigation
while also considering regulatory requirements that govern the licensing
of new therapeutic agents as well as the values of patients whose
outcomes we seek to improve. Heterogeneity in perioperative clinical
trial endpoints and their definitions limits the ability to compare and
interpret differences in outcomes across studies or to pool outcomes
from different studies in meta-analysis. The Standardized Endpoints in
Perioperative Medicine (StEP) initiative is an international
collaboration whose goal is to identify and recommend a suite of clearly
and precisely defined endpoints across multiple domains, specifically
suited for use in perioperative clinical trials. The current review
describes the rationale, goals and the planned pathway of the StEP renal
subgroup. Development of a set of standardized and core renal
endpoints, valid and relevant for use in the perioperative context,
precisely defined and yet with sufficient flexibility to encourage broad
uptake and application should facilitate high-quality and
practice-changing perioperative research into the future.</p>
2017-06-20 11:09:00
Acute renal injury
Kidney injury
Outcome