%0 Generic
%A B., Zhu
%A C., Chen
%A R.K., Moyzis
%A Q., Dong
%A Q., He
%A H.S., Stern
%A H., Li
%A J., Li
%D 2012
%T Supplementary Material for: Genetic Variations in the Dopamine System and Facial Expression Recognition in Healthy Chinese College Students
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Genetic_Variations_in_the_Dopamine_System_and_Facial_Expression_Recognition_in_Healthy_Chinese_College_Students/5122585
%R 10.6084/m9.figshare.5122585.v1
%2 https://karger.figshare.com/ndownloader/files/8707618
%K Facial expression recognition
%K Gene
%K Dopamine
%X Objective: This study investigated the relation between genetic variations in the dopamine system and facial expression recognition. Methods: A sample of Chinese college students (n = 478) was given a facial expression recognition task. Subjects were genotyped for 98 loci [96 single-nucleotide polymorphisms (SNPs) and 2 variable number tandem repeats] in 16 genes involved in the dopamine neurotransmitter system, including its 4 subsystems: synthesis (TH, DDC, and DBH), degradation/transport (COMT,MAOA,MAOB, and SLC6A3), receptors (DRD1,DRD2,DRD3,DRD4, and DRD5), and modulation (NTS,NTSR1,NTSR2, and NLN). To quantify the total contributions of the dopamine system to emotion recognition, we used a series of multiple regression models. Permutation analyses were performed to assess the posterior probabilities of obtaining such results. Results: Among the 78 loci that were included in the final analyses (after excluding 12 SNPs that were in high linkage disequilibrium and 8 that were not in Hardy-Weinberg equilibrium), 1 (for fear), 3 (for sadness), 5 (for anger), 13 (for surprise), and 15 (for disgust) loci exhibited main effects on the recognition of facial expressions. Genetic variations in the dopamine system accounted for 3% for fear, 6% for sadness, 7% for anger, 10% for surprise, and 18% for disgust, with the latter surviving a stringent permutation test. Conclusions: Genetic variations in the dopamine system (especially the dopamine synthesis and modulation subsystems) made significant contributions to individual differences in the recognition of disgust faces.
%I Karger Publishers