%0 Generic %A O., Ahmad %A J., Wardlaw %A W.N., Whiteley %D 2011 %T Supplementary Material for: Correlation of Levels of Neuronal and Glial Markers with Radiological Measures of Infarct Volume in Ischaemic Stroke: A Systematic Review %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Correlation_of_Levels_of_Neuronal_and_Glial_Markers_with_Radiological_Measures_of_Infarct_Volume_in_Ischaemic_Stroke_A_Systematic_Review/5122924 %R 10.6084/m9.figshare.5122924.v1 %2 https://karger.figshare.com/ndownloader/files/8708230 %K Ischaemic stroke %K Blood biomarkers %K Infarct volume %X Background: A blood test that quantified the extent of brain damage following ischaemic stroke might be a useful surrogate outcome measure in trials of acute stroke treatments. Measures of neuronal and glial damage, such as neuron-specific enolase (NSE), glial fibrillary acidic protein, tau-protein, myelin-basic protein and S100-β are potential candidate biomarkers. Aim: We systematically reviewed the relevant literature to find studies that correlated blood levels of neuronal and glial damage markers with imaging measures of infarct volume. Methods: We identified studies with a comprehensive search of databases and the reference lists of relevant studies. We included studies that: (1) measured the highest level, or area under the curve (AUC) over time of markers of cerebral damage, (2) calculated infarct volume, and (3) correlated the two measures. Results: Seventeen studies met the criteria for the systematic review. There were sufficient data to provide summary estimates for S100-β and NSE. The peak level and AUC over time of both markers correlated with subacute infarct volume. Measurements of S100-β later than 24 h after stroke were better correlated with subacute infarct size than earlier measurements. However, scan times varied, and none was later than 8 days after stroke. Conclusion: Peak and AUC levels of NSE and S100-β levels correlated with subacute infarct volume. Correlations of S100-β with infarct volume were stronger when measured after 24 h than closer to admission. Exploratory studies within clinical trials are necessary before blood markers of cerebral tissue damage can be recommended as surrogate endpoints. %I Karger Publishers