P., Suboj S., Babykutty P., Srinivas S., Gopala Supplementary Material for: Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved in the growth-inhibitory activity of this hydroxyanthraquinone in colon cancer cell, WiDr. In our observation AE inhibited cell proliferation by arresting the cell cycle at the G2/M phase and inhibiting cyclin B1. AE appreciably induced cell death specifically through the induction of apoptosis and by activating caspases 9/6. Apoptotic execution was found to be solely dependent on caspase-6 rather than caspase-3 or caspase-7. This is the first study indicating that the AE induces apoptosis specifically through the activation of caspase-6. Caspase;Apoptosis;Colon cancer;Aloe emodin 2012-02-14
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Aloe_Emodin_Induces_G2_M_Cell_Cycle_Arrest_and_Apoptosis_via_Activation_of_Caspase-6_in_Human_Colon_Cancer_Cells/5123185
10.6084/m9.figshare.5123185.v1