Supplementary Material for: Gamma Knife Radiosurgery in the Treatment of Tumor-Related Facial Pain Squire S.E. Chan M.D. Furr R.M. Lowell D.A. Tatter S.B. Ellis T.L. Bourland J.D. deGuzman A.F. Munley M.T. Ekstrand K.E. 10.6084/m9.figshare.5123221.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Gamma_Knife_Radiosurgery_in_the_Treatment_of_Tumor-Related_Facial_Pain/5123221 <i>Background:</i> Intracranial neoplasms can cause pain similar to trigeminal neuralgia. Literature regarding radiosurgery for this is limited. We present a retrospective review of patients with tumor-related facial pain from benign lesions treated with gamma knife radiosurgery (GKRS) at Wake Forest University. <i>Objectives: </i>The primary objectives were to determine long-term pain relief and predictive factors for pain alleviation. <i>Methods:</i> We reviewed 515 patients treated with GKRS for benign meningioma, vestibular schwannoma or trigeminal schwannoma between August 1999 and August 2010. Twenty-one eligible patients had tumor-related facial pain prior to GKRS. The median marginal tumor dose was 12 Gy. Long-term pain relief data were obtained by chart review and telephone interview. <i>Results:</i> The median follow-up for symptom evaluation was 3.8 years. Seventeen of 21 patients (81%) experienced a Barrow Neurological Institute (BNI) score of I–III at 6 months following GKRS. Kaplan-Meier estimates of freedom from BNI IV–V relapse were 66% at 1 year and 53% at 2 years. No pain relapses occurred after 2 years. <i>Conclusion:</i> GKRS of benign lesions is a noninvasive option for patients with tumor-related facial pain. Pain relief is modest, with the majority of pain relapses occurring within 2 years and approximately one half of patients maintaining relief beyond 2 years. 2012-04-11 00:00:00 Benign lesions Gamma knife radiosurgery Facial pain Intracranial tumors