10.6084/m9.figshare.5124067.v1
Tojo G.
Tojo
G.
Fujimura T.
Fujimura
T.
Kambayashi Y.
Kambayashi
Y.
Aiba S.
Aiba
S.
Supplementary Material for: Systemic Lupus Erythematosus Accompanied by Psoriasis Induces IL-27-Producing Cells in Both Affected Areas of the Skin
Karger Publishers
2012
IL-27
Activated antigen-presenting cells
Type 1 helper T cells
2012-08-30 00:00:00
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Systemic_Lupus_Erythematosus_Accompanied_by_Psoriasis_Induces_IL-27-Producing_Cells_in_Both_Affected_Areas_of_the_Skin/5124067
IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.