%0 Generic
%A P., Marques-Vidal
%A M., Bochud
%A F., Bastardot
%A T., Lüscher
%A F., Ferrero
%A J.-M., Gaspoz
%A F., Paccaud
%A A., Urwyler
%A von Känel R.
%A C., Hock
%D 2012
%T Supplementary Material for: Association between Inflammatory and Obesity Markers in a Swiss Population-Based Sample (CoLaus Study)
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Association_between_Inflammatory_and_Obesity_Markers_in_a_Swiss_Population-Based_Sample_CoLaus_Study_/5124226
%R 10.6084/m9.figshare.5124226.v1
%2 https://karger.figshare.com/ndownloader/files/8710534
%K IL-1β
%K IL-6
%K TNF-α
%K hs-CRP
%K BMI
%K Waist circumference
%K Body composition
%K Population study
%X Objective: To assess the associations between obesity markers (BMI, waist circumference and %body fat) and inflammatory markers (interleukin-1β (IL-1β); interleukin-6 (IL-6); tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP)). Methods: Population sample of 2,884 men and 3,201 women aged 35–75 years. Associations were assessed using ridge regression adjusting for age, leisure-time physical activity, and smoking. Results: No differences were found in IL-1β levels between participants with increased obesity markers and healthy counterparts; multivariate regression showed %body fat to be negatively associated with IL-1β. Participants with high %body fat or abdominal obesity had higher IL-6 levels, but no independent association between IL-6 levels and obesity markers was found on multivariate regression. Participants with abdominal obesity had higher TNF-α levels, and positive associations were found between TNF-α levels and waist circumference in men and between TNF-α levels and BMI in women. Obese participants had higher hs-CRP levels, and these differences persisted after multivariate adjustment; similarly, positive associations were found between hs-CRP levels and all obesity markers studied. Conclusion: Obesity markers are differentially associated with cytokine levels. %Body fat is negatively associated with IL-1β; BMI (in women) and waist circumference (in men) are associated with TNF-α; all obesity markers are positively associated with hs-CRP.
%I Karger Publishers