10.6084/m9.figshare.5124367.v1
Li J.
Li
J.
Lu H.
Lu
H.
Tao F.
Tao
F.
Zhou H.
Zhou
H.
Feng G.
Feng
G.
He L.
He
L.
Zhou L.
Zhou
L.
Supplementary Material for: Meta-Analysis of <b><i>MMP9</i></b> –1562C/T and the Risk of Coronary Heart Disease
Karger Publishers
2013
Meta-analysis
Coronary heart disease
Matrix metalloproteinase 9
Genetic polymorphism
2013-01-15 00:00:00
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Meta-Analysis_of_b_i_MMP9_i_b_1562C_T_and_the_Risk_of_Coronary_Heart_Disease/5124367
<b><i>Introduction:</i></b> Previous case-control studies have suggested that the –1562C/T and R279Q polymorphisms of the matrix metalloproteinase 9 gene <i>(MMP9) </i>are associated with coronary heart disease (CHD). However, other studies do not confirm these relationships. The objective is to assess these relationships using meta-analysis. <b><i>Methods:</i></b> Databases, including PubMed and ScienceDirect, were searched to access the genetic association studies. Then data were extracted. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Moreover, subgroup and sensitive analysis were performed. <b><i>Results:</i></b> The meta-analysis of the –1562C/T polymorphism included 12 studies with 8,336 cases and 3,984 controls. The –1562T allele was significantly associated with CHD (OR 1.25, 95% CI 1.08–1.45, p = 0.004). There was heterogeneity among the 12 studies (I<sup>2</sup> = 61%, p = 0.003). The overall results were consistent and were not changed substantially by the removal of any data set. The meta-analysis of the R279Q polymorphism, including 6 studies with 6,983 cases and 3,282 controls, showed that the R279Q polymorphism was not associated with CHD (p = 0.16). <b><i>Conclusions:</i></b> The synthesis of available evidence supports the fact that the <i>MMP9</i> –1562C/T polymorphism is a risk factor for CHD.