Supplementary Material for: Efficient Simulation of Epistatic Interactions in Case-Parent Trios Li Q. Schwender H. Louis T.A. Fallin M.D. Ruczinski I. 10.6084/m9.figshare.5124766.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Efficient_Simulation_of_Epistatic_Interactions_in_Case-Parent_Trios/5124766 Statistical approaches to evaluate interactions between single nucleotide polymorphisms (SNPs) and SNP-environment interactions are of great importance in genetic association studies, as susceptibility to complex disease might be related to the interaction of multiple SNPs and/or environmental factors. With these methods under active development, algorithms to simulate genomic data sets are needed to ensure proper type I error control of newly proposed methods and to compare power with existing methods. In this paper we propose an efficient method for a haplotype-based simulation of case-parent trios when the disease risk is thought to depend on possibly higher-order epistatic interactions or gene-environment interactions with binary exposures. 2013-03-27 00:00:00 Case-parent trios Interactions Single nucleotide polymorphisms Haplotypes