%0 Generic
%A R.L., Koscik
%A La Rue A.
%A E.M., Jonaitis
%A O.C., Okonkwo
%A S.C., Johnson
%A B.B., Bendlin
%A B.P., Hermann
%A M.A., Sager
%D 2014
%T Supplementary Material for: Emergence of Mild Cognitive Impairment in Late Middle-Aged Adults in the Wisconsin Registry for Alzheimer's Prevention
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Emergence_of_Mild_Cognitive_Impairment_in_Late_Middle-Aged_Adults_in_the_Wisconsin_Registry_for_Alzheimer_s_Prevention/5125717
%R 10.6084/m9.figshare.5125717.v1
%2 https://karger.figshare.com/ndownloader/files/8712823
%K Mild cognitive impairment
%K Longitudinal assessment
%K Cognition
%K Robust norms
%X Aim: It is difficult to reliably detect the earliest signs of Alzheimer's disease (AD)-associated cognitive impairment. Our aim was to compare 3 psychometric methods of identifying amnestic mild cognitive impairment (aMCI) in a middle-aged longitudinal cohort enriched for AD risk. Methods: Wisconsin Registry for Alzheimer's Prevention (WRAP) participants with 3 waves of cognitive assessment over approximately 6 years were coded as meeting each of 3 psychometric aMCI definitions: (a) ‘aMCI standard-baseline' used published norms to establish cutoffs for baseline performance; (b) ‘aMCI robust-baseline' applied WRAP-specific robust norms to baseline, and (c) ‘aMCI robust-multiwave' applied these robust norms across 3 waves of assessment. Each group was compared to a cognitively healthy subset. Results: Half the aMCI standard-baseline and one third of the aMCI robust-baseline group reverted to normal ranges at follow-up. Only the aMCI robust-multiwave method had an aMCI × age interaction showing significantly worse age-related memory declines in the aMCI group compared to the cognitively healthy group over 6 years of follow-up. Conclusion: Both cross-sectional methods showed instability over time, with many reverting to normal performance after baseline. The multiwave approach identified a group who showed progressive memory declines over 3 visits. Being able to detect progressive decline in late middle age is a critical step in improving prevention efforts.
%I Karger Publishers