L.-W., Wang Y.-C., Lin S.-T., Wang T.-F., Yeh C.-C., Huang Supplementary Material for: Hypoxic/Ischemic and Infectious Events Have Cumulative Effects on the Risk of Cerebral Palsy in Very-Low-Birth-Weight Preterm Infants <b><i>Background:</i></b> Hypoxia/ischemia and inflammation are two major mechanisms for cerebral palsy (CP) in preterm infants. <b><i>Objective:</i></b> To investigate whether hypoxia/ischemia- and infection-related events in the perinatal and neonatal periods had cumulative effects on CP risk in very-low-birth-weight (VLBW) premature infants. <b><i>Methods:</i></b> From 1995 to 2005, 5,807 VLBW preterm infants admitted to Taiwan hospitals were enrolled.<b> </b>The cumulative effects of hypoxic/ischemic and infectious events during the perinatal and neonatal periods on CP risk at corrected age 24 months were analyzed. <b><i>Results:</i></b> Of the 4,355 infants with 24-month follow-up, 457 (10.5%) had CP. The CP group had significantly higher incidences of hypoxia/ischemia-related events in the perinatal and neonatal periods, and sepsis in the neonatal period than the normal group. Three hypoxic/ischemic events, including birth cardiopulmonary resuscitation (OR 2.25; 95% CI 1.81-2.82), patent ductus arteriosus (PDA) ligation (2.94; 1.35-5.75) and chronic lung disease (3.14; 2.61-3.85) had the most significant contribution to CP. Relative to CP risk for infants with neither the three hypoxic/ischemic events nor sepsis, the CP odds increased 1.98-, 2.26- and 2.15-fold for infants with birth cardiopulmonary resuscitation, PDA ligation and chronic lung disease, respectively; while the combination with sepsis further increased the odds to 3.18-, 3.83- and 3.25-fold, respectively. Using the three hypoxic/ischemic events plus sepsis, CP rates were 10.0, 16.7, 26.7, 40.0 and 54.7% for infants with none, one, two, three and four events, respectively. <b><i>Conclusions:</i></b> Hypoxic/ischemic and infectious events across the perinatal and neonatal periods exerted cumulative effects on CP risk in VLBW premature infants. Cerebral palsy;Hypoxia/Ischemia;Infection;Preterm infants;Very low birth weight 2014-07-05
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Hypoxic_Ischemic_and_Infectious_Events_Have_Cumulative_Effects_on_the_Risk_of_Cerebral_Palsy_in_Very-Low-Birth-Weight_Preterm_Infants/5126521
10.6084/m9.figshare.5126521.v1