10.6084/m9.figshare.5126758.v1 Faber M.A. Faber M.A. De Graag M. De Graag M. Van Der Heijden C. Van Der Heijden C. Sabato V. Sabato V. Hagendorens M.M. Hagendorens M.M. Bridts C.H. Bridts C.H. De Clerck L.S. De Clerck L.S. Ebo D.G. Ebo D.G. Supplementary Material for: Cor a 14: Missing Link in the Molecular Diagnosis of Hazelnut Allergy? Karger Publishers 2014 Atopic dermatitis Bet v 1 Component-resolved diagnosis Cor a 1.04 Cor a 8 Cor a 9 Cor a 11 Cor a 14 Food allergy Hazelnut allergy 2014-07-15 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Cor_a_14_Missing_Link_in_the_Molecular_Diagnosis_of_Hazelnut_Allergy_/5126758 <b><i>Background:</i></b> Hazelnut allergy shows distinct clinical patterns that can be predicted through component-resolved diagnosis. However, identification of sensitization profiles remains incomplete. <b><i>Methods:</i></b> Sera of 75 patients allergic to hazelnuts, 14 infants with atopic dermatitis (AD) sensitized to hazelnuts, 15 hazelnut-tolerant individuals with specific IgE (sIgE) to hazelnuts and 15 healthy control individuals were tested for sIgE reactivity to rCor a 1.04, rCor a 8, nCor a 9, nCor a 11, rCor a 14, rBet v 1, rBet v 2 and cross-reactive carbohydrate determinants (CCDs). <b><i>Results:</i></b> Sensitization to Cor a 14 was observed in 18 out of 20 preschool children, 8 out of 10 school-aged children and 2 out of 7 adults with generalized reactions and in 3 out of 14 infants with AD. Only 2 out of 38 patients with an oral allergy syndrome (OAS) were sensitized to Cor a 14. No sensitization to Cor a 14 was observed in the group of hazelnut-tolerant and healthy control individuals. Sensitization to Cor a 1.04 was seen in 36 out of 38 OAS patients and in 14 out of 37 patients with generalized reactions. However, only 3 patients with generalized reactions were monosensitized to Cor a 1.04. Sensitization to Cor a 9 was observed in 26 out of 37 patients with generalized reactions and in 4 out of 14 infants with AD. Sensitization to Cor a 11, Cor a 8, rBet v 2 and CCDs was rare. <b><i>Conclusions:</i></b> Sensitization to Cor a 14 can have early onset and shows age-related variations. Together with Cor a 9, Cor a 14 enables us to correctly identify almost 90% of children with generalized reactions to hazelnut.