Supplementary Material for: Cor a 14: Missing Link in the Molecular Diagnosis of Hazelnut Allergy? Faber M.A. De Graag M. Van Der Heijden C. Sabato V. Hagendorens M.M. Bridts C.H. De Clerck L.S. Ebo D.G. 10.6084/m9.figshare.5126758.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Cor_a_14_Missing_Link_in_the_Molecular_Diagnosis_of_Hazelnut_Allergy_/5126758 <b><i>Background:</i></b> Hazelnut allergy shows distinct clinical patterns that can be predicted through component-resolved diagnosis. However, identification of sensitization profiles remains incomplete. <b><i>Methods:</i></b> Sera of 75 patients allergic to hazelnuts, 14 infants with atopic dermatitis (AD) sensitized to hazelnuts, 15 hazelnut-tolerant individuals with specific IgE (sIgE) to hazelnuts and 15 healthy control individuals were tested for sIgE reactivity to rCor a 1.04, rCor a 8, nCor a 9, nCor a 11, rCor a 14, rBet v 1, rBet v 2 and cross-reactive carbohydrate determinants (CCDs). <b><i>Results:</i></b> Sensitization to Cor a 14 was observed in 18 out of 20 preschool children, 8 out of 10 school-aged children and 2 out of 7 adults with generalized reactions and in 3 out of 14 infants with AD. Only 2 out of 38 patients with an oral allergy syndrome (OAS) were sensitized to Cor a 14. No sensitization to Cor a 14 was observed in the group of hazelnut-tolerant and healthy control individuals. Sensitization to Cor a 1.04 was seen in 36 out of 38 OAS patients and in 14 out of 37 patients with generalized reactions. However, only 3 patients with generalized reactions were monosensitized to Cor a 1.04. Sensitization to Cor a 9 was observed in 26 out of 37 patients with generalized reactions and in 4 out of 14 infants with AD. Sensitization to Cor a 11, Cor a 8, rBet v 2 and CCDs was rare. <b><i>Conclusions:</i></b> Sensitization to Cor a 14 can have early onset and shows age-related variations. Together with Cor a 9, Cor a 14 enables us to correctly identify almost 90% of children with generalized reactions to hazelnut. 2014-07-15 00:00:00 Atopic dermatitis Bet v 1 Component-resolved diagnosis Cor a 1.04 Cor a 8 Cor a 9 Cor a 11 Cor a 14 Food allergy Hazelnut allergy