D., Ray X., Li W., Pan J.S., Pankow S., Basu Supplementary Material for: A Bayesian Partitioning Model for the Detection of Multilocus Effects in Case-Control Studies <b><i>Background:</i></b> Genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with complex diseases, but these variants appear to explain very little of the disease heritability. The typical single-locus association analysis in a GWAS fails to detect variants with small effect sizes and to capture higher-order interaction among these variants. Multilocus association analysis provides a powerful alternative by jointly modeling the variants within a gene or a pathway and by reducing the burden of multiple hypothesis testing in a GWAS. <b><i>Methods:</i></b> Here, we propose a powerful and flexible dimension reduction approach to model multilocus association. We use a Bayesian partitioning model which clusters SNPs according to their direction of association, models higher-order interactions using a flexible scoring scheme and uses posterior marginal probabilities to detect association between the SNP set and the disease. <b><i>Results:</i></b> We illustrate our method using extensive simulation studies and applying it to detect multilocus interaction in Atherosclerosis Risk in Communities (ARIC) GWAS with type 2 diabetes. <b><i>Conclusion:</i></b> We demonstrate that our approach has better power to detect multilocus interactions than several existing approaches. When applied to the ARIC study dataset with 9,328 individuals to study gene-based associations for type 2 diabetes, our method identified some novel variants not detected by conventional single-locus association analyses. Dimension reduction;Multilocus interaction;Reversible jump Markov chain Monte Carlo 2015-06-03
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Bayesian_Partitioning_Model_for_the_Detection_of_Multilocus_Effects_in_Case-Control_Studies/5127376
10.6084/m9.figshare.5127376.v1