K.L., Hildreth Van Pelt R.E. K.L., Moreau J., Grigsby K.F., Hoth V., Pelak C.A., Anderson B., Parnes J., Kittelson P., Wolfe Supplementary Material for: Effects of Pioglitazone or Exercise in Older Adults with Mild Cognitive Impairment and Insulin Resistance: A Pilot Study <b><i>Aims:</i></b> To examine the effects of pioglitazone or endurance exercise training on cognitive function in older adults with mild cognitive impairment (MCI) and insulin resistance. <b><i>Methods:</i></b> Seventy-eight adults (mean age ± SD: 65 ± 7 years) with central obesity and MCI were randomized to<b> </b>6 months of endurance exercise, pioglitazone or control.<b><i> Results:</i></b> Sixty-six participants completed the study. Exercise training did not significantly increase peak oxygen uptake compared to control (p = 0.12). Compared to control, insulin resistance improved in the pioglitazone group (p = 0.002) but not in the exercise group (p = 0.25). There was no measureable effect of pioglitazone or exercise on cognitive performance compared to control. <b><i>Conclusion:</i></b> In this pilot study, pioglitazone improved insulin resistance but not cognitive performance in older adults with MCI and insulin resistance. Mild cognitive impairment;Insulin resistance;Pioglitazone;Exercise 2015-02-20
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Effects_of_Pioglitazone_or_Exercise_in_Older_Adults_with_Mild_Cognitive_Impairment_and_Insulin_Resistance_A_Pilot_Study/5127544
10.6084/m9.figshare.5127544.v1