%0 Generic %A C.J., Child %A G., Kalifa %A C., Jones %A J.L., Ross %A G.A., Rappold %A C.A., Quigley %A A.G., Zimmermann %A G., Garding %A G.B., Cutler Jr. %A W.F., Blum %D 2015 %T Supplementary Material for: Radiological Features in Patients with Short Stature Homeobox-Containing (SHOX) Gene Deficiency and Turner Syndrome before and after 2 Years of GH Treatment %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Radiological_Features_in_Patients_with_Short_Stature_Homeobox-Containing_b_i_SHOX_i_b_Gene_b_b_Deficiency_and_Turner_Syndrome_before_and_after_2_Years_of_GH_Treatment/5127916 %R 10.6084/m9.figshare.5127916.v1 %2 https://karger.figshare.com/ndownloader/files/8715841 %2 https://karger.figshare.com/ndownloader/files/8715844 %K SHOX deficiency %K Turner syndrome %K Growth hormone %K Radiology %X Background/Aims: The short stature homeobox-containing (SHOX) gene is one of many genes that regulate longitudinal growth. The SHOX deficiency (SHOX-D) phenotype, caused by intragenic or regulatory region defects, ranges from normal stature to mesomelic skeletal dysplasia. We investigated differences in radiological anomalies between patients with SHOX-D and Turner syndrome (TS) and the effect of 2 years of growth hormone (GH) treatment on these anomalies. Methods: Left hand/wrist, forearm and lower leg radiographs were assessed at baseline and after 2 years in children with genetically confirmed SHOX-D (GH-treated and untreated groups) and TS (GH-treated) in a randomised, controlled, multinational study. Results: Radiological anomalies of hand, wrist and forearm were common in SHOX-D and TS. Radial bowing appeared more prevalent in SHOX-D, while lower leg anomalies were more common in TS. There were no significant differences in radiological findings between GH-treated and untreated patients with SHOX-D after 2 years. Conclusion: GH treatment had no systematic effect on skeletal findings in SHOX-D, based on limited radiological differences between the GH-treated and untreated groups at 2 years. Bone age radiographs allow assessment of radiological signs indicating a potential diagnosis of SHOX-D and may lead to earlier genetic confirmation and initiation of GH therapy. %I Karger Publishers