%0 Generic
%A J.E., Ostergren
%A M.C., Gornick
%A D.A., Carere
%A S.S., Kalia
%A W.R., Uhlmann
%A M.T., Ruffin
%A J.L., Mountain
%A R.C., Green
%A J.S., Roberts
%D 2015
%T Supplementary Material for: How Well Do Customers of Direct-to-Consumer Personal Genomic Testing Services Comprehend Genetic Test Results? Findings from the Impact of Personal Genomics Study
%U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_How_Well_Do_Customers_of_Direct-to-Consumer_Personal_Genomic_Testing_Services_Comprehend_Genetic_Test_Results_Findings_from_the_Impact_of_Personal_Genomics_Study/5128177
%R 10.6084/m9.figshare.5128177.v1
%2 https://karger.figshare.com/ndownloader/files/8716246
%K Commercial genetics
%K Direct-to-consumer genetic testing
%K Personal genomic testing
%K Public health policy
%K Risk comprehension
%X Aim: To assess customer comprehension of health-related personal genomic testing (PGT) results. Methods: We presented sample reports of genetic results and examined responses to comprehension questions in 1,030 PGT customers (mean age: 46.7 years; 59.9% female; 79.0% college graduates; 14.9% non-White; 4.7% of Hispanic/Latino ethnicity). Sample reports presented a genetic risk for Alzheimer's disease and type 2 diabetes, carrier screening summary results for >30 conditions, results for phenylketonuria and cystic fibrosis, and drug response results for a statin drug. Logistic regression was used to identify correlates of participant comprehension. Results: Participants exhibited high overall comprehension (mean score: 79.1% correct). The highest comprehension (range: 81.1-97.4% correct) was observed in the statin drug response and carrier screening summary results, and lower comprehension (range: 63.6-74.8% correct) on specific carrier screening results. Higher levels of numeracy, genetic knowledge, and education were significantly associated with greater comprehension. Older age (≥60 years) was associated with lower comprehension scores. Conclusions: Most customers accurately interpreted the health implications of PGT results; however, comprehension varied by demographic characteristics, numeracy and genetic knowledge, and types and format of the genetic information presented. Results suggest a need to tailor the presentation of PGT results by test type and customer characteristics.
%I Karger Publishers