%0 Generic %A J.E., Ostergren %A M.C., Gornick %A D.A., Carere %A S.S., Kalia %A W.R., Uhlmann %A M.T., Ruffin %A J.L., Mountain %A R.C., Green %A J.S., Roberts %D 2015 %T Supplementary Material for: How Well Do Customers of Direct-to-Consumer Personal Genomic Testing Services Comprehend Genetic Test Results? Findings from the Impact of Personal Genomics Study %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_How_Well_Do_Customers_of_Direct-to-Consumer_Personal_Genomic_Testing_Services_Comprehend_Genetic_Test_Results_Findings_from_the_Impact_of_Personal_Genomics_Study/5128177 %R 10.6084/m9.figshare.5128177.v1 %2 https://karger.figshare.com/ndownloader/files/8716246 %K Commercial genetics %K Direct-to-consumer genetic testing %K Personal genomic testing %K Public health policy %K Risk comprehension %X Aim: To assess customer comprehension of health-related personal genomic testing (PGT) results. Methods: We presented sample reports of genetic results and examined responses to comprehension questions in 1,030 PGT customers (mean age: 46.7 years; 59.9% female; 79.0% college graduates; 14.9% non-White; 4.7% of Hispanic/Latino ethnicity). Sample reports presented a genetic risk for Alzheimer's disease and type 2 diabetes, carrier screening summary results for >30 conditions, results for phenylketonuria and cystic fibrosis, and drug response results for a statin drug. Logistic regression was used to identify correlates of participant comprehension. Results: Participants exhibited high overall comprehension (mean score: 79.1% correct). The highest comprehension (range: 81.1-97.4% correct) was observed in the statin drug response and carrier screening summary results, and lower comprehension (range: 63.6-74.8% correct) on specific carrier screening results. Higher levels of numeracy, genetic knowledge, and education were significantly associated with greater comprehension. Older age (≥60 years) was associated with lower comprehension scores. Conclusions: Most customers accurately interpreted the health implications of PGT results; however, comprehension varied by demographic characteristics, numeracy and genetic knowledge, and types and format of the genetic information presented. Results suggest a need to tailor the presentation of PGT results by test type and customer characteristics. %I Karger Publishers