10.6084/m9.figshare.5128585.v1 Baumann P. Baumann P. Fouzas S. Fouzas S. Pramana I. Pramana I. Grass B. Grass B. Niesse O. Niesse O. Bührer C. Bührer C. Spanaus K. Spanaus K. Wellmann S. Wellmann S. Supplementary Material for: Plasma Proendothelin-1 as an Early Marker of Bronchopulmonary Dysplasia Karger Publishers 2015 Chronic lung disease Prematurity Neonate Biomarker Vasoactive peptide 2015-09-11 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Plasma_Proendothelin-1_as_an_Early_Marker_of_Bronchopulmonary_Dysplasia/5128585 <b><i>Background:</i></b> Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants. Clinical prediction of BPD at an early stage in life is difficult. Plasma proendothelin-1 (CT-proET-1) is a lung injury biomarker in pulmonary hypertension and respiratory distress. <b><i>Objective:</i></b> To assess the prognostic ability of CT-proET-1 in BPD. <b><i>Methods:</i></b> In 227 prospectively enrolled preterm infants born at <32 weeks gestational age (GA), plasma CT-proET-1 was measured at birth, day of life (DOL) 2, 3, 6 and 28, and at 36 weeks postmenstrual age (PMA). BPD was defined as mild in infants requiring supplemental oxygen at DOL 28 and moderate/severe in those requiring it at 36 weeks PMA. <b><i>Results:</i></b> The predictive ability of CT-proET-1 for any BPD was poor at birth [area under the ROC curve (AUC) 0.654, 95% CI 0.494-0.814], moderate at DOL 2 and 3 (AUC 0.769, 95% CI 0.666-0.872) and excellent at DOL 6 (AUC 0.918, 95% CI 0.840-0.995). Multivariable regression analysis revealed that CT-proET-1 levels at DOL 2, 3, 6 and 28 were strongly related to the duration of oxygen supplementation, independently of GA and the duration of respiratory support. <b><i>Conclusions:</i></b> CT-proET-1 is a novel promising biomarker for predicting the development of BPD in preterm infants when measured at the end of the first week of life.