Supplementary Material for: Femoral Access and Delivery of Continuous Renal Replacement Therapy Dose Bellomo R. Mårtensson J. Lo S. Kaukonen K.-M. Cass A. Gallagher M. 10.6084/m9.figshare.5128744.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Femoral_Access_and_Delivery_of_Continuous_Renal_Replacement_Therapy_Dose/5128744 <b><i>Aims:</i></b> The study aims to describe the use of dialysis catheters in critically ill patients treated with continuous renal replacement therapy (CRRT) and to study the impact of femoral versus non-femoral access on CRRT dose. <b><i>Methods:</i></b> Statistical analysis and predictive modelling of data from the Randomized Evaluation of Normal vs. Augmented Level renal replacement therapy trial. <b><i>Results:</i></b> The femoral vein was the first access site in 937 (67%) of 1,399 patients. These patients had higher Acute Physiology and Chronic Health Evaluation and Sequential Organ Failure Assessment scores (p = 0.009) and lower pH (p < 0.001) but similar mortality to patients with non-femoral access (44 vs. 45%; p = 0.63). Lower body weight was independently associated with femoral access placement (OR 0.97, 95% CI 0.96-0.98). Femoral access was associated with a 1.03% lower CRRT dose (p = 0.05), but a 4.20% higher dose was achieved with 13.5 Fr catheters (p = 0.03). <b><i>Conclusions:</i></b> Femoral access was preferred in lighter and sicker patients. Catheter gauge had greater impact than catheter site in CRRT dose delivery. Video Journal Club “Cappuccino with Claudio Ronco” at http://www.karger.com/?doi=439581. 2015-10-20 00:00:00 Dialysis Continuous renal replacement therapy Catheters Femoral vein Intensive care