L., Perna U., Mons D., Rujescu M., Kliegel H., Brenner Supplementary Material for: Apolipoprotein E e4 and Cognitive Function: A Modifiable Association? Results from Two Independent Cohort Studies <b><i>Background:</i></b> The apolipoprotein E <i>(APOE)</i> e4 genetic polymorphism is a major risk factor for Alzheimer' s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. <b><i>Methods:</i></b> We used linear regression models to assess associations of <i>APOE</i> e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n = 366), and restricted cubic splines to explore dose-response relationships between serum cholesterol levels and cognition depending on <i>APOE</i> polymorphism. <b><i>Results:</i></b> The association of <i>APOE</i> e4 with cognitive function was strongly amplified in the presence of hypercholesterolemia and cardiovascular disease in both independent cohorts; hypercholesterolemia was associated with cognitive function only among <i>APOE</i> e4 carriers in the presence of cardiovascular disease. The interaction effect between <i>APOE</i> genotype and hypercholesterolemia was statistically significant in both cohorts. <b><i>Conclusions:</i></b> The detrimental effects of <i>APOE</i> e4 polymorphism on cognition may strongly depend on modifiable risk factors. Prevention;Risk factors;Alzheimer’s disease;Cognitive decline;Hypercholesterolemia 2015-10-24
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Apolipoprotein_E_e4_and_Cognitive_Function_A_Modifiable_Association_Results_from_Two_Independent_Cohort_Studies/5128774
10.6084/m9.figshare.5128774.v1