Supplementary Material for: Patterns and Mechanisms of Artificial Kidney Failure during Continuous Renal Replacement Therapy Zhang L. Tanaka A. Zhu G. Baldwin I. Eastwood G.M. Bellomo R. 10.6084/m9.figshare.5129035.v1 https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Patterns_and_Mechanisms_of_Artificial_Kidney_Failure_during_Continuous_Renal_Replacement_Therapy/5129035 <b><i>Background:</i></b> We aimed to describe the previously unstudied relationship between circuit pressures and circuit clotting, here labeled as ‘artificial kidney failure' (AKF), in patients receiving continuous renal replacement therapy (CRRT). <b><i>Methods:</i></b> We performed an observational study of CRRT-treated critically ill patients to continuously record the multiple CRRT circuit pressures. <b><i>Results:</i></b> Three patterns of access outflow dysfunction (AOD) were also noted: severe, moderate and mild. Compared with circuits without AOD, circuits experiencing at least one AOD episode had shorter lifespans (14.2 ± 12.7 vs. 21.3 ± 16.5 h, p = 0.057). This effect was more obvious with moderate or severe AOD (8.7 ± 4.6 vs. 20.6 ± 15.7 h, p = 0.007). If any AOD events occurred within the first 4 h, the sensitivity and specificity in predicting early-immediate AKF were 53.4 and 94.4%, respectively. <b><i>Conclusions:</i></b> Early and intermediate AKF during CRRT is most likely dependent on AOD, which is a frequent event with variable severity. 2015-12-16 00:00:00 Transmembrane pressure Critical illness Artificial kidney failure Access outflow dysfunction Circuit pressure