J.A., Grieger V.L., Clifton A.R., Tuck A.L., Wooldridge S.A., Robertson K.L., Gatford Supplementary Material for: In utero Programming of Allergic Susceptibility <b><i>Background:</i></b> Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. <b><i>Methods:</i></b> A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. <b><i>Results:</i></b> Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. <b><i>Conclusion:</i></b> To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions. Diet;Allergy;Developmental programming;Epigenetics;Prenatal risk factors 2016-04-05
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_In_utero_Programming_of_Allergic_Susceptibility/5129395
10.6084/m9.figshare.5129395.v1