Supplementary Material for: Aortic Valve Gradient and Clinical Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis
Witberg G.
Barsheshet A.
Assali A.
Vaknin-Assa H.
Shaul A.A.
Orvin K.
Vaturi M.
Schwartzenberg S.
Shapira Y.
Sagie A.
10.6084/m9.figshare.5129401.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Aortic_Valve_Gradient_and_Clinical_Outcome_in_Patients_Undergoing_Transcatheter_Aortic_Valve_Implantation_for_Severe_Aortic_Stenosis/5129401
<b><i>Objectives:</i></b> To explore the relation between the baseline aortic valve gradient (AVG) as a continuous variable and clinical outcomes following transcatheter aortic valve implantation (TAVI) in general and specifically in patients with high-gradient aortic stenosis (AS). <b><i>Methods:</i></b> We reviewed 317 consecutive patients who underwent TAVI at our institution. We investigated the relation between AVG as a continuous/categorical variable and outcome among all patients and in patients without low-flow low-gradient AS, using the Cox proportional hazard model adjusting for multiple prognostic variables. <b><i>Results:</i></b> Patients had a peak AVG of 79.9 ± 22.8 mm Hg (mean 50.5 ±15.7). During a mean follow-up of 2.7 years, AVG was inversely associated with mortality and mortality or cardiac hospitalization. Every 10-mm-Hg increase in peak AVG was associated with 18% reduction in mortality (p = 0.003) and 19% reduction in mortality/cardiac hospitalization (p < 0.001). Every 10-mm-Hg increase in mean AVG was associated with a 24% reduction in both outcomes (p = 0.005 and p < 0.001). Subgroup analysis of patients with left-ventricular ejection fraction >40% or peak AVG >64 mm Hg yielded similar results. <b><i>Conclusions:</i></b> Mean and peak baseline AVGs are directly associated with improved outcomes after TAVI; AVG can be used to select the patients most likely to benefit from TAVI.
2016-03-09 00:00:00
Aortic stenosis
Transcatheter aortic valve implantation
Aortic valve gradients