10.6084/m9.figshare.5129734.v1 Kim C. Kim C. Jung J.Y. Jung J.Y. Kim Y.S. Kim Y.S. Lee J.S. Lee J.S. Rhee C.K. Rhee C.K. Lee J.H. Lee J.H. Lee J.-H. Lee J.-H. Kim T.-H. Kim T.-H. Lim S.Y. Lim S.Y. Sheen S.S. Sheen S.S. Supplementary Material for: Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease Karger Publishers 2016 Chronic obstructive pulmonary disease Vitamin D deficiency Exercise capacity Six-minute walk distance 2016-04-23 00:00:00 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Vitamin_D_Deficiency_Is_Associated_with_Rapid_Decline_in_Exercise_Capacity_in_Male_Patients_with_Chronic_Obstructive_Pulmonary_Disease/5129734 <b><i>Background:</i></b> Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. <b><i>Objectives:</i></b> The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. <b><i>Methods:</i></b> A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity ≥17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). <b><i>Results:</i></b> Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). <b><i>Conclusion:</i></b> This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD.