10.6084/m9.figshare.5172991.v1
Abe M.
Abe
M.
Hamano T.
Hamano
T.
Wada A.
Wada
A.
Nakai S.
Nakai
S.
Masakane I.
Masakane
I.
Supplementary Material for: High-Performance Membrane Dialyzers and Mortality in Hemodialysis Patients: A 2-Year Cohort Study from the Annual Survey of the Japanese Renal Data Registry
Karger Publishers
2017
Dialyzer
Hemodialysis
High-flux membrane
High-performance membrane
2017-07-05 06:33:34
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_High-Performance_Membrane_Dialyzers_and_Mortality_in_Hemodialysis_Patients_A_2-Year_Cohort_Study_from_the_Annual_Survey_of_the_Japanese_Renal_Data_Registry/5172991
<p><b><i>Background:</i></b> Little information is available regarding
the type of dialyzer which results in good prognosis. This study is
aimed at investigating the association between 7 types of dialyzers and
2-year mortality. <b><i>Methods:</i></b> We conducted a cohort study
using data from a nationwide registry of the Japanese Society for
Dialysis Therapy. Subjects were 136,676 patients on maintenance
hemodialysis (HD) between 2009 and 2011 who underwent maintenance HD for
at least 2 years and were treated with one of the following 7 types of
high-performance membrane dialyzers: cellulose triacetate (CTA),
ethylene vinyl alcohol (EVAL), polyacrylonitrile (PAN), polyester
polymer alloy (PEPA), polyethersulfone (PES), polymethylmethacrylate
(PMMA), and polysulfone (PS). Cox regression was used to estimate the
association between baseline dialyzers and all-cause 2-year mortality,
adjusting for potential confounders. <b><i>Results:</i></b> Data were
adjusted using basic factors, with PS as a reference group, and the
hazard ratio (HR) was significantly higher in CTA, PMMA, PAN, and EVAL
groups. Further data adjustment for Kt/V yielded the same results as
were obtained from data adjusted for basic factors. After further
adjustment for nutrition- and inflammation-related factors, HR was
significantly lowered for the PES and PMMA groups compared with the PS
group (HR 0.88; 95% CI 0.82-0.94 and HR 0.84 95% CI 0.76-0.93,
respectively). After propensity score matching, HR for the PES and PMMA
groups was significantly lowered compared with the PS group. <b><i>Conclusions:</i></b>
The use of different membrane types may affect mortality. Further
long-term prospective studies are needed to clarify whether the PES and
PMMA membranes can improve prognosis.</p>