E., Israel J.M., Drazen S.B., Liggett H.A., Boushey R.M., Cherniack V.M., Chinchilli D.M., Cooper J.V., Fahy J.E., Fish J.G., Ford Erratum: Effect of Polymorphism of the β<sub>2</sub>-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma <i>Background:</i> Regular use of inhaled β-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the β<sub>2</sub>-adrenergic receptor (β<sub>2</sub>-AR) can affect its regulation; however, results of smaller studies of the effects of such polymorphisms on response to β-agonist therapy have been inconsistent. <i>Methods:</i> We examined the possible effects of polymorphisms at codons 16 (β<sub>2</sub>-AR-16) and 27 (β<sub>2</sub>-AR-27) on response to albuterol by genotyping 190 asthmatics who had participated in a trial of regular versus as-needed albuterol use. <i>Results:</i> During the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at β<sub>2</sub>-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF). This effect was magnified during a 4-week run-out period, when all patients returned to as-needed albuterol only. By the end of the study, Arg/Arg subjects who had used albuterol regularly had an AM PEF 30.5 ± 12.1 liters/min lower (p = 0.012) than Arg/Arg patients who had used albuterol as needed only. Subjects homozygous for glycine at β<sub>2</sub>-AR-16 showed no such decline. Evening PEF also declined in the Arg/Arg regular but not in as-need albuterol users. No significant differences between regular and as-needed treatment were associated with polymorphisms at β<sub>2</sub>-AR-27. <i>Conclusions:</i> Polymorphisms of the β<sub>2</sub>-AR may influence airway responses to regular inhaled β-agonist treatment. Asthma;β2-Adrenergic agonists;β2-Adrenergic receptor;Albuterol 2017-07-25
    https://karger.figshare.com/articles/dataset/Erratum_Effect_of_Polymorphism_of_the_sub_2_sub_-Adrenergic_Receptor_on_Response_to_Regular_Use_of_Albuterol_in_Asthma/5241058
10.6084/m9.figshare.5241058.v1