%0 Generic %A M.-J., Kim %A S.-A., Park %A C.H., Kim %A S.-Y., Park %A J.-S., Kim %A D.-K., Kim %A J.-S., Nam %A Y.Y., Sheen %D 2017 %T Erratum: TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition %U https://karger.figshare.com/articles/dataset/Erratum_TGF-_Type_I_Receptor_Kinase_Inhibitor_EW-7197_Suppresses_Cholestatic_Liver_Fibrosis_by_Inhibiting_HIF1_-Induced_Epithelial_Mesenchymal_Transition/5241841 %R 10.6084/m9.figshare.5241841.v1 %2 https://karger.figshare.com/ndownloader/files/8956561 %K Cholestatic liver injury %K Hepatic stellate cell %K TGF-β %K HIF1α %K Epithelial mesenchymal transition %K EW-7197 %X Background/Aims: Hypoxia is an environmental factor that aggravates liver fibrosis. HIF1α activates hepatic stellate cells (HSCs) and increases transforming growth factor-β (TGF-β) signaling and the epithelial mesenchymal transition (EMT), accelerating the progression of fibrosis. We evaluated the anti-fibrotic therapeutic potential of a small-molecule inhibitor of TGF-β type I receptor kinase, EW-7197, on HIF1α-derived TGF-β signaling in cholestatic liver fibrosis. Methods: We used a bile duct ligation (BDL)-operated rat model to characterize the role of HIF1α-derived TGF-β signaling in liver fibrosis. Cellular assays were performed in LX-2 cells (human immortalized HSCs). The anti-fibrotic effects of EW-7197 in liver tissues and HSCs were investigated via biochemical assays, immunohistochemistry (IHC), immunofluorescence (IF), chromatin immunoprecipitation (ChIP) assays, real-time PCR, and western blotting. Results: In our BDL rat model, orally administered EW-7197 inhibited fibrosis and attenuated HIF1α-induced activation of HSCs and EMT in vivo. In addition, EW-7197 inhibited HIF1α-derived HSC activation and expression of EMT markers in LX-2 cells in vitro. Conclusion: This study suggests that EW-7197 exhibits potential as a treatment for liver fibrosis because it inhibits HIF1α-induced TGF-β signaling. %I Karger Publishers