10.6084/m9.figshare.5267782.v1
Li E.S.
Li
E.S.
Görens I.
Görens
I.
Cheung P.-Y.
Cheung
P.-Y.
Lee T.-F.
Lee
T.-F.
Lu M.
Lu
M.
O'Reilly M.
O'Reilly
M.
Schmölzer G.M.
Schmölzer
G.M.
Supplementary Material for: Chest Compressions during Sustained Inflations Improve Recovery When Compared to a 3:1 Compression:Ventilation Ratio during Cardiopulmonary Resuscitation in a Neonatal Porcine Model of Asphyxia
Karger Publishers
2017
Infants
Newborns
Neonatal resuscitation
Chest compressions
Sustained inflation
Asphyxia
2017-08-02 12:11:53
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Chest_Compressions_during_Sustained_Inflations_Improve_Recovery_When_Compared_to_a_3_1_Compression_Ventilation_Ratio_during_Cardiopulmonary_Resuscitation_in_a_Neonatal_Porcine_Model_of_Asphyxia/5267782
<p><b><i>Background:</i></b> Recently, sustained inflations (SI) during
chest compression (CC) (CC+SI) have been suggested as an alternative to
the current approach during neonatal resuscitation. No previous study
compared CC+SI using CC rates of 90/min to the current 3:1
compression:ventilation ratio (C:V). <b><i>Objective:</i></b> To
determine whether CC+SI versus a 3:1 C:V reduces the time to the return
of spontaneous circulation (ROSC) and improves hemodynamic recovery in
newborn piglets with asphyxia-induced bradycardia. <b><i>Intervention and Measurements:</i></b>
Term newborn piglets were anesthetized, intubated, instrumented, and
exposed to 45-min normocapnic hypoxia followed by asphyxia.
Cardiopulmonary resuscitation (CPR) was initiated when the heart rate
decreased to 25% of baseline. Piglets were randomized into 3 groups: CC
during SI at a rate of 90 CC/min (SI+CC 90, <i>n</i> = 8), a 3:1 C:V using 90 CC and 30 inflations (3:1, <i>n</i> = 8), or a sham group (<i>n</i>
= 6). Cardiac function, carotid blood flow, cerebral oxygenation, and
respiratory parameters were continuously recorded throughout the
experiment. <b><i>Results:</i></b> CC+SI significantly reduced the median (IQR) time of ROSC, i.e., 34 s (28-156 s) versus 210 s (72-300 s) in the 3:1 group (<i>p</i>
= 0.048). CC+SI also significantly reduced the requirement for 100%
oxygen, improved respiratory parameters, and resulted in a similar
hemodynamic recovery. <b><i>Conclusions:</i></b> CC+SI during CPR
significantly improved ROSC in a porcine model of neonatal
resuscitation. This is of considerable clinical relevance because
improved respiratory and hemodynamic parameters potentially minimize
morbidity and mortality in newborn infants.</p>