Supplementary Material for: Tracking Cognitive Decline in Amnestic Mild Cognitive Impairment and Early-Stage Alzheimer Dementia: Mini-Mental State Examination versus Neuropsychological Battery
Kim J.
Na H.K.
Byun J.
Shin J.
Kim S.
Lee B.H.
Na D.L.
10.6084/m9.figshare.5267815.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Tracking_Cognitive_Decline_in_Amnestic_Mild_Cognitive_Impairment_and_Early-Stage_Alzheimer_Dementia_Mini-Mental_State_Examination_versus_Neuropsychological_Battery/5267815
<p><b><i>Background/Aims:</i></b> Although the Mini-Mental State
Examination (MMSE), Clinical Dementia Rating-Sum of Boxes (CDR-SOB), and
neuropsychological batteries are widely used for evaluating cognitive
function, it remains elusive which instrument best reflects the
longitudinal disease progression in amnestic mild cognitive impairment
(aMCI) and probable Alzheimer disease (AD). We investigated whether
changes in these three instruments over time correlate with loss of
cortical gray matter volume (cGMV). <b><i>Methods:</i></b> We retrospectively investigated 204 patients (aMCI, <i>n</i> = 114; AD, <i>n</i>
= 90) who had undergone MMSE, CDR-SOB, the dementia version of the
Seoul Neuropsychological Screening Battery (SNSB-D), and 3-dimensional
T1-weighted magnetic resonance images at least twice. We investigated
the partial correlation between annual decline in test scores and
percent change of cGMV. <b><i>Results:</i></b> In aMCI patients, changes in the SNSB-D total score (<i>r</i> = 0.340, <i>p</i> < 0.001) and CDR-SOB (<i>r</i> = 0.222, <i>p</i>
= 0.020), but not MMSE, showed a correlation with cGMV loss, with the
SNSB-D total score showing the strongest correlation. In AD patients,
decline in all three test scores correlated significantly with cGMV
loss, with MMSE exhibiting the strongest correlation (<i>r</i> = 0.464, <i>p</i> < 0.001). <b><i>Conclusion:</i></b>
In aMCI patients, neuropsychological battery, though time-consuming,
was the most adequate tool in tracking disease progression. In AD
patients, however, MMSE may be the most effective longitudinal
monitoring tool when considering cost-effectiveness.</p>
2017-08-02 12:37:19
Alzheimer disease
Mild cognitive impairment
Mini-Mental State Examination
Neuropsychological tests
Longitudinal study
Magnetic resonance imaging