10.6084/m9.figshare.5267824.v1
Schietroma M.
Schietroma
M.
Pessia B.
Pessia
B.
Colozzi S.
Colozzi
S.
Carlei F.
Carlei
F.
Clementi M.
Clementi
M.
Amicucci G.
Amicucci
G.
Guadagni S.
Guadagni
S.
Supplementary Material for: Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers
Karger Publishers
2017
Gut barrier function
Inflammatory serum markers
Extraperitoneal rectal cancer
Rectal surgery
2017-08-02 12:49:39
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Septic_Complications_after_Resection_for_Middle_or_Low_Rectal_Cancer_Role_of_Gut_Barrier_Function_and_Inflammatory_Serum_Markers/5267824
<p><b><i>Background:</i></b> The focus of this study was to understand
the relationship between the failure of gut barrier function,
inflammatory markers and septic complications after resection for
extraperitoneal rectal cancer. <b><i>Methods:</i></b> One hundred seven
patients were enrolled into this prospective observational study and
underwent open colorectal resection for extraperitoneal cancer. All
patients underwent an assessment of intestinal permeability (L/M ratio),
endotoxemia, interleukin-1β (IL-1β), interleukin-6 (IL-6), C-reactive
protein (CRP) and elastase levels before surgery and on postoperative
days 1, 3, and 7. <b><i>Results:</i></b> Septic complications developed
in 23.3% of patients. There were no significant differences in
preoperative L/M ratio, endotoxine, CRP, interleukin-1 (IL-1), IL-6, and
elastase levels between septic and non-septic groups. All patients
showed a significant increase in intestinal permeability, endotoxemia,
IL-1, IL-6, CRP, and elastase on the first postoperative day. At
postoperative day 7, the septic group continued to demonstrate an
increase in intestinal permeability, endotoxemia and elastase and
significant difference was observed between the 2 groups (<i>p</i> < 0.05), whereas there was no significant difference in IL-1, IL-6, and CRP levels. <b><i>Conclusion:</i></b>
The pattern of change in the postoperative period of intestinal
permeability, systemic endotoxemia and elastase concentration is
significantly higher in patients in whom sepsis develops, while the
concentration of IL-1β, IL-6, and CRP does not permit to distinguish
infection from inflammation.</p>