10.6084/m9.figshare.5419039.v1
Choi Y.-L.
Choi
Y.-L.
Cho E.Y.
Cho
E.Y.
Kim J.H.
Kim
J.H.
Nam S.J.
Nam
S.J.
Oh Y.L.
Oh
Y.L.
Song S.Y.
Song
S.Y.
Yang J.-H.
Yang
J.-H.
Kim D.S.
Kim
D.S.
Supplementary Material for: Detection of Human Papillomavirus DNA by DNA Chip in Breast Carcinomas of Korean Women
Karger Publishers
2017
Breast cancer
Chip
HPV DNA chip typing
Papillomavirus, human
2017-09-19 14:05:27
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Detection_of_Human_Papillomavirus_DNA_by_DNA_Chip_in_Breast_Carcinomas_of_Korean_Women/5419039
<p>It remains unclear whether there is an association between human
papillomavirus (HPV) infection and human breast cancer. The aim of this
study was to investigate the presence of HPV DNA in breast carcinomas of
Korean women and to examine the possible association between HPV and
breast cancer development. For this purpose, HPV DNAs from 154 patients,
including 123 patients with breast carcinoma and 31 with intraductal
papilloma, and nipple tissue from 27 cancer patients were examined using
the DNA chip method. HPV DNA was detected in 8 breast carcinomas (6.5%)
but in no intraductal papilloma. All detected HPV genotypes were of
high-risk groups. There was a slightly increased incidence in papillary
carcinomas (11.5%) and invasive ductal carcinomas with adjacent
intraductal papillomas (11.8%) compared to the other histological
subtypes (3.2–4.3%), although the difference was not statistically
significant (p = 0.126). The presence of HPV DNA was not correlated with
specific prognostic predictors of disease. High-risk HPV DNA sequences
were present in 6.5% of Korean patients with breast tumors. However,
this study could not demonstrate whether or not such HPVs directly
contribute to the development of breast cancer.</p>