Supplementary Material for: Treatment with Haemodiafiltration Stabilises Vascular Stiffness (Measured by Aortic Pulse Wave Velocity) Compared to Haemodialysis
Charitaki E.
Belman D.
Davenport A.
10.6084/m9.figshare.5492848.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Treatment_with_Haemodiafiltration_Stabilises_Vascular_Stiffness_Measured_by_Aortic_Pulse_Wave_Velocity_Compared_to_Haemodialysis/5492848
<p><b><i>Background/Aims:</i></b> Cerebrovascular diseases such as
stroke are increased in dialysis patients, and haemodiafiltration has
been reported to reduce cerebrovascular mortality compared to
haemodialysis. We wished to determine whether haemodiafiltration
improves arterial stiffness. <b><i>Methods:</i></b> We audited aortic
pulse wave velocity (PWV) measurements 6 months apart in 3 cohorts of
patients: 69 treated with haemodialysis, 78 who converted from
haemodialysis to haemodiafiltration and 142 treated with
haemodiafiltration. <b><i>Results:</i></b> Cohorts were well matched for
age (means ± SD: haemodialysis 64 ± 15 years vs. haemodialysis to
haemodiafiltration 64 ± 17 years vs. haemodiafiltration 67 ± 16 years),
sex (male 65 vs. 59 vs. 63%), diabetes (45 vs. 56.4 vs. 44%) and body
mass index (26 ± 6 vs. 26 ± 5 vs. 26 ± 5), respectively. Systolic blood
pressure did not differ over time (haemodialysis 143 ± 25 vs. 146 ± 27
mm Hg, haemodialysis to haemodiafiltration 153 ± 26 vs. 154 ± 25 mm Hg,
haemodiafiltration 149 ± 31 vs. 148 ± 30 mm Hg) or between groups.
Aortic PWV significantly increased in the haemodialysis group (9.5 ± 1.9
vs. 10.2 ± 2.2 m/s, p < 0.01) and haemodialysis to
haemodiafiltration group (9.4 ± 1.9 vs. 10.1 ± 2.2 m/s, p < 0.01),
but did not change with haemodiafiltration (9.9 ± 2.1 vs. 10.1 ± 2.2
m/s). <b><i>Conclusions:</i></b> Aortic PWV, a measure of vascular
stiffness, stabilised with haemodiafiltration. Our preliminary findings
require further investigation to determine how haemodiafiltration may
potentially improve vascular stiffness.</p>
2017-10-12 13:46:31
Hypertension
Haemodiafiltration
Haemodialysis
Pulse wave velocity
Vascular calcification